Regional tourist cooperation has become one of the trends of tourist development which has already been in full swing in China’s Yangtze River Delta Pearl River Delta and other regions. Chongqing and Sichuan are close geographically with identical culture origin. There has a good basis and superiority of cooperation in tourism. Trough analyzing the conditions and obstacles of Chongqing-Sichuan tourist cooperation it is still at the initial stage. The cooperation aims are just limited to the removal of institutional barriers; the contents are gathered much to the communication between the two areas; the form which is typical government promotion and industrial connection has not formed a fixed mode of cooperation. Regional tourist cooperation should be based on the space organization structure and take industrial organizations as two wings in order to achieve a win-win goal of cooperation. Based on those, this paper puts forwards the dual-nucleus model which should be adopted by Chongqing and Sichuan tourist cooperation, that is, taking Chengdu and main city of Chongqing as Dual-nucleus; building the tourist circle of the Yangtze River upper reaches in space; setting up intergovernmental organizations and establishing a cooperation mechanism; constructing strategic alliances to establish partnership relations and realizing the docking of industrial chain in the aspect of industry. By so doing we shall have obtain from the above three aspects to promote tourist development throughout the whole region.