［Purposes］The ecological management of mountain, water, forest, field, lake, and grass in the Yangtze River Economic Zone (YREZ) is a century-old plan for the sustainable development. ［Methods］The mountain-water-forest-field-lake-grass (MWFFLG) life community in the YREZ was taken as the research object, based on the construction of the health diagnosis system of the MWFFLG life community, the Normal Cloud Model were used to diagnose the health status of the MWFFLG life community, and analyze the coupling and coordination relationship among the different subsystems. ［Results］1) The overall health status of the MWFFLG life community in the YREZ from 2000 to 2018 showed an improvement trend; spatially, the health ranking was in the order: Midstream >Upstream > Downstream. 2) The longitudinal diagnosis results of the health status of different subsystems were: field subsystem>water subsystem>mountain subsystem>grass subsystem>lake subsystem>forest subsystem. 3) There were 46 system combinations in the coupling associations among the six subsystems in the YREZ, most of which had coupling indices exceeding 0.8, which were all at a high level of coupling; however, the coordination coefficients of most system combinations were slightly out of adjustment (0.3-0.5). 4) Forestry yield, forest stock volume, lake area, per capita aquatic products, and total fishery output value were the main driving factors for the health of the MWFFLG life community in the YREZ. ［Conclusions］The MWFFLG life community in the YREZ had been developing in a healthy way, and the coupling and coordination among systems were on the rise.